Forward Jeff Green scored a season-high 31 points -- also a season high for his team -- and guard Avery Bradley (9-for-12 from the floor) added 21 points to lead the Celtics (7-11), who shot 11-for-23 from 3-point range.
Guard Jordan Crawford delivered a triple-double -- 11 points, 11 rebounds and 10 assists -- and forwards Brandon Bass and Jared Sullinger added 12 points apiece. Bass added eight rebounds and four assists and Sullinger scored all of his points via 3-pointers.
Green has 57 points the last two games.
The Cavaliers, who shot 37.2 percent from the floor, fell behind by 16 quickly and never really got back into it, losing their fifth straight game to fall to 4-12.
The Celtics, who led by as many as 25 points, scored the game's first five points and, after Irving got his team on the board, ran off 13 more and led 18-2 6:18 into the game. The Cavaliers would wind up 4-for-19 from the floor in the quarter, the Celtics leading by 18 at the end of one.
The visitors were a bit better in the second quarter but the Boston lead was 16 at the break. Before the second half was nine minutes old, the Celtics, 3-for-4 from 3-point range after the break -- would be up by 25.
NOTES: The Celtics wrap up an 18-game month of November with Saturday night's game at Milwaukee that also wraps up the sixth of back-to-back dates of the month. December brings just 12 games, which allows more practice time for the young team. ... The Cavaliers host the Chicago Bulls on Saturday. ... F Kelly Olynyk (right ankle sprain) and G Courtney Lee (sore knee) were out for the Celtics, with Olynyk wearing a protective boot. ... With F C.J. Miles still out with a calf injury, rookie G/F Sergei Karasev made his first NBA starts for the Cavaliers. ... Cleveland coach Mike Brown's son, Elijah, signed with Butler just before then-Butler coach Brad Stevens left for the Boston job. "Brad is such a class guy, and when he did leave, I don't know if you can handle it any better," Mike Brown said. Elijah Brown is averaging 8.3 points per game at Butler, scoring 15 in Friday's loss to No. 5 Oklahoma State.