Brooklyn (10-20) fought hard but was held back by a porous defense that allowed Indiana to match a season best with 53.5 percent shooting from the field.
Playing without star center Brook Lopez and key frontcourt reserves Andrei Kirilenko and Andray Blatche, the Nets simply didn't have enough and dropped to 0-3 against Indiana. They shot 46.8 percent from the field but were outrebounded 41-28.
The Pacers, who came in outscoring opponents by an average of 5.9 points in the third quarter, stayed true to form and outscored the Nets 28-20 in the third to seize a firm grip on what had been a high-scoring game. That gave Indiana an 86-76 lead entering the fourth quarter.
The Nets scored on their first five possessions of the second quarter, causing Indiana coach Frank Vogel to call timeout with 8:55 remaining as Brooklyn took a 38-35 lead. Things got worse out of the stoppage when Pierce stole a pass and dribbled for an open-court dunk that gave the Nets a 43-37 advantage.
NOTES: Saturday's game began a nine-game stretch in which the Nets will face seven teams with winning records. ... Brooklyn announced that C Brook Lopez will have surgery on Jan. 4 to repair the fractured fifth metatarsal of his right foot. The team did not reveal a timetable for his recovery. ... The sellout crowd was the ninth at Bankers Life Fieldhouse. Last season, the Pacers had just 10 home sellouts in the regular season. ... Pacers F/G Paul George's 3-pointer with 2:56 left in the first half tied him with Austin Croshere (376 3s made) for seventh place on the franchise's career list.