Anthony, the Knicks' leading scorer this season at 26.3 points per game, came to Madison Square Garden on Wednesday morning with the intention to play, but he was ruled out 20 minutes before the start of the game, the team announced on Twitter.
The ankle injury occurred Monday night during the Knicks' 103-98 victory over the Orlando Magic when Anthony's left foot rolled after he landed on the foot of Orlando's Tobias Harris with 7:26 left in the third quarter. The All-Star is averaging 8.8 rebounds and 2.8 assists per game this season.
Anthony's absence left the game without a marquee matchup between the NBA's two leading scorers last season -- Anthony and Thunder forward Kevin Durant.
The Knicks also were missing injured point guard Raymond Felton, leaving New York with a starting lineup of Beno Udrih, Iman Shumpert, J.R. Smith, Andrea Bargnani and Tyson Chandler.