SIU-Edwardsville (1-5) lost all three of its games in the round-robin affair.
The Ramblers took a 73-70 lead with 1:20 left in the game but saw the Cougars make it a one-point game on Donivine Stewart's jumper with 1:02 remaining. Stewart also was fouled but missed the free throw.
The Ramblers lost the ball with 37 seconds left, but after a timeout with 31.2 seconds on the clock, the Cougars had to rush to beat the shot clock and Stewart missed a hurried jumper.
Both teams shot well with Loyola shooting 57.1 percent from on 28-of-49 shooting from the field and SIU-Edwardsville 50.9 percent on 27-of-53 shooting.
The Ramblers had four players in double figures with Christian Thomas, Jeff White, and O'Leary sharing top honors with 14 points each. Nick Osborne had 10.
SIU-Edwardsville's Stewart led all scorers with 22 points. Michael Messer with 14 was the only other Cougar in double figures.