DeRozan, a guard-forward, scored 34 points and Lowry, a guard, generated 18 points, 13 assists and 10 rebounds for the Atlantic Division-leading Raptors (22-20), who won their second straight and ended a four-game road losing streak.
Like DeRozan, Lowry was tracking Anthony's effort on his cell phone after the game -- and after Lowry, a PHILADELPHIA native and Villanova graduate, fashioned his first triple-double of the season and the fourth of his career. It came before "50-something" friends and family members.
"It's always special to play here," he said. "Even if I play terrible and we win the game, and I give my family something to cheer for, I'm happy."
The triple-double made it more so.
"As long as it's with a win, it's a great feat," he said. "As long as it's with a win, I'm happy to have it."
Guard Michael Carter-Williams had 20 points to lead PHILADELPHIA (14-29), which lost for the fourth time in five games. Forward Thaddeus Young added 16 points and guard-forward Hollis Thompson had 15. Center Spencer Hawes contributed 14 points and 12 rebounds.
DeRozan, who scored a career-high 40 points in Wednesday night's victory over Dallas, notched 16 in the fourth quarter when the Raptors outscored the Sixers 24-17. Four of his points came in a 9-0 run that allowed Toronto to extend an 87-83 lead to 96-83 with 4:47 remaining.
The Sixers, who made 6 of 20 shots from the field in the fourth quarter, drew no closer than six thereafter.
"At the end of the day, they're a good team," Young said. "I don't look past them or anything like that. There used to be a point where the Toronto Raptors walk in and you're like, 'OK, this can be an easy one.' But we know they have a lot of key guys on that team who can do a lot of different things."
And their chemistry appears to have improved since the Gay trade.
"You miss all the shots you don't take -- that's how I look at it," he said. "My team needs me to shoot, especially when the game gets close, whenever we need a bucket, so I can't have that mindset, 'I missed nine in a row,' whatever it may be. I've just got to keep being aggressive."
NOTES: The Sixers have lost eight of their last 10 at home. ... Earlier in the day, the Sixers signed C Dewayne Dedmon to a second 10-day contract. The 7-foot rookie is, at age 23, "incredibly raw," coach Brett Brown said before tipoff, having only begun playing basketball five years ago. But like fellow G-F Hollis Thompson, Dedmon is "not polluted," Brown said, and doesn't have a lot of bad habits that need to be corrected. "I've seen a lot of excellent things from Dewayne," Brown said. "I think that he's got a future in the NBA." ... Raptors F Tyler Hansbrough (left ankle sprain) missed his 12th straight game. ... Sixers G Tony Wroten (right ankle sprain) sat out his third straight.